| Pair Name | Pterostilbene, TNF-related apoptosis inducing ligand | ||
| Phytochemical Name | Pterostilbene (PubChem CID: 5281727 ) | ||
| Anticancer drug Name | TNF-related apoptosis inducing ligand (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Pterostilbene, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Activity | DDIT3 | hsa1649 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| Up-regulation | Expression | TNFRSF10A | hsa8797 | |
| Up-regulation | Expression | TNFRSF10B | hsa8795 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP8 | hsa841 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| In Vitro Model | BT-20 | Invasive breast carcinoma | Homo sapiens (Human) | CVCL_0178 |
| Result | Pterostilbene enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistance triple negative breast cancer cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Pterostilbene Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors and Downregulation of Cell Survival Proteins in TRAIL-Resistance Triple Negative Breast Cancer Cells. J Agric Food Chem. 2017 Dec 27;65(51):11179-11191. doi: 10.1021/acs.jafc.7b02358. | Click |
